Urine is strong and can irritate her skin and cause her pain. How much you spending on laundering the soiled bedding and washing your dog? For as much as she loves us unconditionally we should spoil her, not torture.

Good luck. We have tried incurin. My vet first prescribed the tablets which my friend’s dog ate like treats unfortunately that was not my experience with mine. Human Warnings: Not for human use. You can break up Proin into quarters and give her a small bit 3-4X daily.

“Studies have shown that up to 20 percent of spayed dogs leak urine when resting or sleeping,” Dr. Nichol said. Half on the floor, the walls, me. Sprinkle it with a tablespoon of wet food at breakfast and mixed into her meal at dinner. The combination treatment is believed to provide a synergistic effect, meaning the combination may be more effective than either drug alone. Give them Proin. And she has increased chance for UTIs which are very painful. There are two generally accepted treatments for hormonal urinary incontinence.

My first dog loved it. Incurin is indicated for the treatment of urinary incontinence due to sphincter mechanism incontinence (SMI) in spayed female dogs. The most common side effects associated with Incurin treatment included a loss of appetite, vomiting, excessive water drinking and swollen vulva. I know she is miserable, and I can hardly take it anymore.

Incurin is made by Merck Animal Health and is available in a 1 mg estriol (sometimes referred to as oestriol) tablet.

Find honest and helpful reviews for Incurin (Estriol) Tablets for Dogs at Chewy.com. I researched this and talked to a number of people so far and I would be very grateful to anyone who could solve this problem for me, since I have to give him this for the rest of his life. My vet told me to contact a compounding pharmacy which I did ,they stated they made that in six different flavors I’ve tried two so far, he hates all equally so far which has made it very difficult, this has made it much less likely to stay consistent and giving him this dose which is necessary every day at this point. Please refer to Animal Drugs @ FDA for more information about INCURIN, PROIN, and PROIN ER. I’m looking for someone or anyone or a company that can tell me how I can solve this issue. In the second part of the clinical field study (180 days), PROIN achieved 98.1% owner satisfaction for the control of urinary incontinence.) Dosage and Administration. Urethral sphincter mechanism incontinence, or urethral sphincter hypotonus, is more common than many practitioners believe, said Albuquerque, N.M., veterinarian Jeff Nichol, DVM, who practices behavior medicine at the Veterinary Emergency and Specialty Center, and general medicine at Petroglyph Animal Hospital. PROIN and PROIN ER are the only FDA-approved animal drugs that contain phenylpropanolamine as the active ingredient. I am going to buy her some diapers today. If you have any questions regarding your pet’s incontinence, contact your veterinarian to schedule an appointment. The drug’s labeling is truthful, complete, and not misleading. It was terrible as we were looking for an underlying cause.

My dog is 9, been on Proin since 10 weeks old.

I use a pill crusher or just crush it with a spoon when I can’t locate my crusher. I am not aware of any injectable medicine that will help a pet control urinary incontinence. She was in rescue and spayed at 10 weeks, before we got her. She usually gets about half in her mouth cuz she shakes her head. Yes I don’t understand all these reactions unless the side affects are so bad the dogs associated to the pill and are smarter than you think. For more information, please contact CVM’s Education & Outreach Staff at 240-402-7002 or AskCVM@fda.hhs.gov. Good Luck. It was extremely bitter almost caustic. Manufactured by Intervet, Inc., INCURIN is a prescription drug available in 1 mg strength tablets [New Animal Drug Application (NADA) 141-325]. Incurin is indicated for the treatment of urinary incontinence due to sphincter mechanism incontinence (SMI) in spayed female dogs. Has. – Donna R. Answer:

I can’t afford it anymore and nothing else is working. Incurin – The second prescription we use is Incurin.

Incurin tablets are given orally. Easier for the dog to take and digest. Diethylstilbestrol usually starts with a loading phase including five to seven days of daily treatment. The company’s marketing communications related to the drug to make sure the information is truthful and not misleading. However she HATES it. In very rare cases vaginal bleeding and hair loss can be seen.

Worked. Below are the most common side effects of Proin (or Phenylpropanolamine) Hope this helps. The .gov means it’s official.Federal government websites often end in .gov or .mil. I gave it once to my Lab and she almost stroked out – panting, and snarling, pacing for hours. FDA rigorously evaluates an animal drug before approving it. She acts like she’s being punished after I get one down and we’re doing this twice a day. She was in rescue and spayed at 10 weeks, before we got her. You may notice incontinence occurring at routine times, including when your dog is sleeping, or at less predictable times up to several times per day. The drug’s safety and effectiveness.

Possible side effects have included signs of estrus (in heat), swollen vulva/teats and nausea. She has TERRIBLE skin problems, almost unbearable during the summer (in FL it’s always summer). We wrap our proin in a small meat ball made of turkey and put it in the freezer until needed. Diethylstilbestrol is no longer made by a drug manufacturer and must be obtained through a compounding pharmacy like VetRxDirect. We have tried incurin. Treatment is recommended to be started at one tablet per day for 7 to 14 days. The only offense here is the cost of blood testing every 6 months to maintain a prescription for pro in. Incurin should not be used in animals less than 1 year old. Rare side effects may include vaginal bleeding and hair loss. In a margin of safety study, phenylpropanolamine hydrochloride (PPA) was administered to dogs twice daily at 1X, 3X or 5X the recommended dose (2 mg/kg) for 182 days. Having worked in a hospital pharmacy for 25 years myself, I knew this was used as a human drug originally and I happen to get a small drop on my finger which I just briefly touched my tongue it affected me the same way as my dog. It’s a large enough pill that it’s hard to force it down. Very expensive. It was terrible as we were looking for an underlying cause. I feel so bad for her because she was house broken at 9 weeks and never went in the house..she is so humiliated when it happens.

That was the only med she was taking. No offense, but proin is one of the cheaper meds. We started our female dog on Incurin in late March 2019. She only eats once a day. Click to share on Facebook (Opens in new window), Click to share on Twitter (Opens in new window), Click to share on Pinterest (Opens in new window), Incurin: New FDA Approved Drug for Urinary Incontinence, phenylpropanolamine, also known as PPA (Proin, Propalin), estrogen product called diethylstilbestrol, also referred to as DES, estrogen treatment option named Incurin (estriol). Took her outside to “walk it off” after mistakenly thinking some food would “dilute” the affects. Is Incurin safer since it is a natural estrogen? Frequently the dogs are not aware that they are leaking urine. I have not yet started her on it, but I was doing some reading up on it, as I hate to put my pets on any medications. Bailey is only a year old, and her occasional bouts of incontinence did not start until after she was spayed. Incurin: The newest drug for urinary incontinence in spayed female dogs.

This year they deemed her thyroid “perfectly normal”, although last year, it was “questionable”, and I wonder if a thyroid medication would help her, and believe she may have a problem with her thyroid after all. This has proven to be both safe (if given at the prescribed doses) and effective (In an FDA approved 28 day clinical trial PROIN reduced mean urinary accidents per week in female dogs by 82%. “My experie… As long as the drug company markets the animal drug, the agency continues to monitor: FDA’s Center for Veterinary Medicine (CVM) is committed to promoting and protecting animal health by ensuring that safe and effective drugs are available for animals. PROIN ER (phenylpropanolamine hydrochloride extended-release) Tablets. We here to answer any questions you have.

1025 E. Ray Road #5 Physical examination and blood and urine tests are usually normal in these pets. June 3rd she had a grand mal seizure. It’s a traumatic event for all involved when I do give it to her. I just paid out the nose for it at my vet : 90 for 180 50mg tabs. I had a similar experience I am taking my dog off of it. Proin, PPA for Urinary Incontinence in Spayed Dogs. In 2011, FDA approved both INCURIN (estriol) Tablets and PROIN (phenylpropanolamine hydrochloride) Chewable Tablets to control urinary incontinence in dogs. Sometimes, the agency’s post-approval monitoring uncovers safety and effectiveness issues that were unknown at the time of approval; The manufacturing process to ensure quality and consistency are maintained from batch to batch; The drug’s labeling to make sure the information remains truthful, complete, and not misleading; and. Oasis Animal Hospital is proud to serve the following areas: Vision and Mission of Oasis Animal Hospital. If you or your pet’s veterinarian have questions about either of the drugs reviewed in this post, give us call. Does anyone have any experience with these three meds used to treat incontinence: Proin, Incurin, and DES? She experienced some definite side effects. An official website of the United States government, : If you can get Proin online or at one of the Big Box stores and it is the identical product, not short dated (where the expiration date is nearly due or past due) go for it. We tried to give her breakfast and dinner, but she rarely ever ate breakfast until dinner time. Adverse Effects: Restlessness, irritability, hypertension, & anorexia. Three products are FDA-approved to control urinary incontinence in dogs: INCURIN is the first, and so far only, FDA-approved animal drug that contains estriol as the active ingredient. Here are links to additional information about Proin and Incurin. Please respond with answers for us and any other information you can provide. Thanks in advance.

Her teeth are big. The most pronounced effects of treatment were a dose-dependent increase in blood pressure, and a dose dependent decrease in heart rate. Before sharing sensitive information, make sure you're on a federal government site. He seems to find it extremely offencive. The initial dose rate of Incurin is 1 tablet per dog per day. This condition will usually start months to years after being spayed. Chris please don’t let her live out her days peeing herself. We searched web for side effects of this medication and didn’t find seizures as one if them. Pill pockets and peanut butter have limited success. You should consult your veterinarian if you notice any side effects and keep all follow-up appointments. One of our loyal clients recently asked… “Hey Dr. Tenney: This study demonstrated the safety of phenylpropanolamine administered to dogs at 2, 6 and 10 mg/kg twice daily for 6 months. We give her a special towel and treats. Wash your hands with soap and water after administration to avoid exposure to the drug. Nothing. Estrogens increase the resting muscle tone of the urethra in females and can be used to treat female dogs with urinary incontinence due to estrogen depletion. Estrogens and alpha-adrenergic agonists are the two drug classes identified to help increase urethral sphincter tone. She is now not just leaking, but full on, full bladder like in a fast drip, until she is soaking EVERYTHING.